Human Chorionic Gonadotropin is a hormone that mimics the action of Luteinizing Hormone (LH). In men, it is primarily used alongside Testosterone Replacement Therapy (TRT) to stimulate the testes, thereby preventing testicular atrophy and maintaining fertility. Its relevance to healthspan is indirect, serving as a supportive therapy to mitigate side effects of another intervention rather than being a primary longevity agent itself.
Verdict
Supportive therapy for TRT; not a standalone longevity intervention.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
High
EVIDENCE GRADE
A
MONTHLY COST
$50 - $100
Protocol
- Typically used adjunctively with TRT at 250-500 IU injected subcutaneously 2-3 times per week.
Flags
- Requires a prescription and medical supervision.
- Can significantly increase estradiol levels, potentially causing gynecomastia.
- Long-term use may desensitize Leydig cells to LH.
- Contraindicated in individuals with certain hormone-sensitive cancers (e.g., prostate cancer).
- Use for weight loss (the 'hCG diet') is ineffective and widely discredited.