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Glycolic Acid (Topical)

Alpha Hydroxy Acid, AHA

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Meta Information

ID:glycolic-acid-aha
Name:Glycolic Acid
Schema Version:1.5

Alternate Names

  • Alpha Hydroxy Acid
  • AHA

Active Compound

glycolic acid

Intervention Type

therapeutic_agent

Delivery

Route:
topical_skin
Scope:
  • local

Is Skin Health

True

Regulatory Status

  • us:otc_drug
  • us:cosmetic

Indication

Focus:
healthspan
Description:
Improves skin texture, tone, and reduces signs of photodamage and aging locally.

Typical Protocol

  • Apply a 5-10% glycolic acid serum or cream to clean skin daily or several times per week.
  • Professional chemical peels use higher concentrations (20-70%) administered infrequently by a clinician.

Expected Cost Mean

Low Cost:
15
High Cost:
60
Cost Type:
monthly
Description:
Monthly cost for over-the-counter products, generally not insurance covered.

Summary

Glycolic acid, an Alpha Hydroxy Acid, exfoliates the outermost layer of skin cells, promoting cellular turnover. This process can reduce the appearance of fine lines, hyperpigmentation, and improve skin texture and elasticity. It also supports collagen synthesis, contributing to skin integrity and a youthful appearance, which can be considered a local aspect of healthspan.

Purpose

Enhances skin health and appearance by exfoliating and stimulating renewal.

Card Summary

Exfoliates skin, improves texture, reduces fine lines, and supports collagen for local skin healthspan.

Drug Class

alpha_hydroxy_acid

Drugs In Class

Empty Array

Impact

Score:
5.5
Justification:
Targets skin aging markers and appearance; local, not systemic healthspan benefit.

Evidence

Grade:
A
Score:
9
Justification:
Extensive human RCTs confirm efficacy for skin texture, tone, and photodamage.

Safety

Score:
4.5
Justification:
Common side effects: irritation, sun sensitivity; generally safe for topical use.

Flags

  • Increases skin sensitivity to sun; mandatory daily broad-spectrum SPF use.
  • May cause initial irritation, redness, or stinging, especially with higher concentrations.
  • Avoid concurrent use with other strong exfoliants like retinoids or benzoyl peroxide without professional guidance.

Verdict

Improve skin health, manage exfoliation, and prioritize sun protection.