Glucosamine and chondroitin are natural components of cartilage. As supplements, they are proposed to support cartilage structure and reduce joint pain and stiffness in osteoarthritis by providing building blocks for cartilage repair and potentially anti-inflammatory effects. Evidence for direct healthspan extension is lacking.
Verdict
Targeted joint support for osteoarthritis symptoms; no direct healthspan impact.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$10 - $40
Protocol
- Commonly dosed at 1500 mg/day for glucosamine and 1200 mg/day for chondroitin, often taken together.
Flags
- May interact with anticoagulants like warfarin, increasing bleeding risk.
- Efficacy for joint pain is inconsistent across studies.
- Individuals with shellfish allergies should use glucosamine cautiously.