Meta Information

ID:ghk-cu

Name:Ghk-Cu

Schema Version:1.5

Alternate Names

• Copper Peptide
• GHK-Copper

Active Compound

glycyl-l-histidyl-l-lysine-copper

Intervention Type

therapeutic_agent

Delivery

Route:

topical_skin

Scope:

• local

Is Skin Health

True

Regulatory Status

• us:cosmetic_ingredient

Indication

Focus:

healthspan

Description:

Targets visible signs of skin aging, such as wrinkles and loss of elasticity, by promoting tissue repair and collagen synthesis.

Typical Protocol

• Apply a serum or cream with a 1-3% concentration to the target skin area once or twice daily.

Expected Cost Mean

Low Cost:

30

High Cost:

100

Cost Type:

monthly

Description:

Cost for commercial serums or creams; not covered by insurance.

Summary

GHK-Cu is a naturally occurring copper-peptide complex that declines with age. Applied topically, it is believed to stimulate collagen and elastin production, improve tissue repair, and exert anti-inflammatory and antioxidant effects. These actions can improve skin elasticity and firmness and reduce the appearance of fine lines, contributing to the healthspan of the skin as an organ.

Purpose

A copper-peptide that promotes skin repair and collagen synthesis.

Card Summary

A naturally occurring copper peptide used topically to promote skin repair, collagen synthesis, and reduce visible signs of aging.

Drug Class

null

Drugs In Class

Empty Array

Impact

Score:

4.2

Justification:

Provides targeted benefits for skin health and appearance, a component of healthspan.

Evidence

Grade:

B

Score:

6.5

Justification:

Supported by small human clinical trials and extensive in-vitro data for skin rejuvenation.

Safety

Score:

2.5

Justification:

Generally well-tolerated topically with rare, mild skin irritation as the primary side effect.

Flags

• May cause mild, temporary skin irritation, redness, or itching in sensitive individuals.
• Ensure product is from a reputable source to avoid contaminants or incorrect concentrations.
• Systemic effects from standard topical application are considered negligible.

Verdict

A low-risk, evidence-based topical for improving skin health and appearance.

Qualifier

topical

Created

2026-05-05T21:59:34.692286Z

Ai Model

Gemini 2.5 Pro (High)