Galanthamine is a plant-derived alkaloid that acts as a reversible acetylcholinesterase inhibitor, increasing the neurotransmitter acetylcholine in the brain. It is primarily approved for mild to moderate Alzheimer's disease. Its relevance to healthspan is based on its potential to support cognitive function, memory, and mitigate age-related neuroinflammation, though evidence in healthy aging populations is limited.
Verdict
A potential cognitive tool with limited evidence for broad healthspan benefits.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Moderate
EVIDENCE GRADE
B
MONTHLY COST
$20 - $45
Protocol
- Take 4-8 mg before bed or upon waking for cognitive enhancement or lucid dreaming induction.
Flags
- Common side effects include nausea, vomiting, diarrhea, and dizziness.
- May cause bradycardia (slow heart rate) and should be used with caution in individuals with cardiac conditions.
- Interacts with anticholinergic drugs, beta-blockers, and other cholinesterase inhibitors.
- Use with caution in individuals with a history of seizures, asthma, or peptic ulcers.