Folate is an essential B-vitamin critical for one-carbon metabolism, which governs DNA synthesis, repair, and methylation. Maintaining adequate folate status supports epigenetic stability and helps regulate homocysteine levels, a risk factor for cardiovascular and neurodegenerative diseases. As an intervention, it aims to optimize these fundamental cellular processes that can degrade with age.
Verdict
Essential for methylation; ensure adequacy, especially if MTHFR variant is present.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$5 - $20
Protocol
- Daily supplementation ranges from 400 to 1000 mcg, often as L-methylfolate for superior bioavailability.
Flags
- High doses of synthetic folic acid can mask a Vitamin B12 deficiency.
- Individuals with MTHFR gene variants may have impaired conversion of folic acid to its active form.
- The L-methylfolate (5-MTHF) form bypasses MTHFR conversion issues and is often preferred.
- Interacts with methotrexate, certain anti-seizure medications (e.g., phenytoin), and sulfasalazine.