Fisetin is a plant-derived flavonoid investigated for its senolytic properties—the ability to selectively clear dysfunctional, senescent cells. These 'zombie' cells accumulate with age and contribute to chronic inflammation. The liposomal formulation encapsulates fisetin in lipids to significantly enhance its poor natural bioavailability, aiming for more effective systemic delivery and cellular uptake.
Verdict
A promising experimental senolytic, but human healthspan evidence remains preliminary.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
C
MONTHLY COST
$30 - $70
Protocol
- Take 100-500 mg daily for 2-3 consecutive days.
- Repeat this short 'hit-and-run' cycle once per month or as clinically guided.
Flags
- Liposomal delivery significantly increases bioavailability; do not use standard fisetin dosages.
- May interact with anticoagulant and antiplatelet drugs (blood thinners).
- Long-term safety of periodic high-dose senolytic therapy in humans is unknown.
- Quality and dosage can vary significantly between supplement manufacturers.