← Back to Directory

Fasting-Mimicking Diet (FMD)

FMD, Prolon Diet

Visual ViewRaw Data

Meta Information

ID:fasting-mimicking-diet
Name:Fasting-Mimicking Diet (FMD)
Schema Version:1.5

Title

Fasting-Mimicking Diet (FMD)

Alternate Names

  • FMD
  • Prolon Diet

Intervention Type

dietary_practice

Expected Cost Mean

Low Cost:
150
High Cost:
250
Cost Type:
one time
Description:
Cost per 5-day cycle, typically for a pre-packaged commercial kit.

Summary

The Fasting-Mimicking Diet is a periodic, low-calorie dietary program designed to confer the metabolic and cellular benefits of prolonged water-only fasting while minimizing the burden of complete food abstinence. By providing specific macro- and micronutrients, it aims to downregulate pro-aging pathways like IGF-1 and mTOR while activating cellular cleanup (autophagy) and stem cell-based regeneration. The goal is to induce a rejuvenating state that reduces risk factors for age-related diseases.

Purpose

Periodic dietary protocol that mimics fasting to promote cellular rejuvenation.

Card Summary

A 5-day diet that mimics fasting to trigger autophagy and stem cell regeneration.

Drug Class

Drugs In Class

Empty Array

Impact

Score:
7.2
Justification:
Induces potent cellular renewal pathways like autophagy and stem cell regeneration.

Evidence

Grade:
B
Score:
6.5
Justification:
Human RCTs show metabolic benefits, but long-term healthspan data is limited.

Safety

Score:
3.8
Justification:
Generally safe for healthy individuals but poses risks for specific populations.

Flags

  • Not recommended for individuals who are underweight, pregnant, or have eating disorders.
  • Requires medical supervision for individuals with diabetes or other metabolic diseases.
  • Can cause temporary side effects like fatigue, headaches, and dizziness.
  • Potential for muscle loss if protein intake is inadequate post-cycle.

Verdict

A potent, periodic reset for cellular health with moderate human evidence.

Created

2026-04-23T23:32:32.260419Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
none
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
The Fasting-Mimicking Diet is a periodic, low-calorie dietary program designed to confer the metabolic and cellular benefits of prolonged water-only fasting while minimizing the burden of complete foo...

Typical Protocol

  • A 5-day, low-calorie, low-protein, low-sugar diet performed once every 1-6 months.