Famotidine is a histamine H2-receptor antagonist that works by selectively blocking H2 receptors on parietal cells in the stomach, which reduces gastric acid secretion. This action is highly effective for treating and preventing conditions caused by excess stomach acid, such as peptic ulcers and GERD, allowing esophageal and stomach tissue to heal.
Verdict
Highly effective and safe for treating acid-related gastrointestinal disorders.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$5 - $20
Protocol
- For treating GERD or ulcers, 20-40 mg is typically taken once or twice daily.
- For preventing or treating heartburn, 10-20 mg is taken as needed 15-60 minutes before meals.
Flags
- Long-term use may be associated with vitamin B12 deficiency.
- Dose adjustment may be required for individuals with impaired kidney function.
- Can mask symptoms of more serious conditions like stomach cancer; consult a doctor for persistent symptoms.
- Rarely, can cause confusion or delirium, particularly in the elderly or those with renal impairment.