Meta Information
ID:estradiol-valerate
Name:
Schema Version:AIM-2.0
Created
2026-05-10T18:59:12.991913Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/intervention/saint-johns-wort
Target name:
Saint John's Wort
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
This herb strongly accelerates estradiol breakdown, severely reducing its effectiveness and causing treatment failure.
Actionable advice:
Avoid combination completely.
Target id:
/class/anticonvulsants
Target name:
Enzyme-Inducing Anticonvulsant Medications
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Certain seizure medications significantly lower estradiol levels, reducing its effectiveness and causing breakthrough bleeding.
Actionable advice:
Dose adjustment may be required.
Target id:
/class/selective-estrogen-receptor-modulators
Target name:
Selective Estrogen Receptor Modulators (SERMs)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
SERMs interfere with estradiol at its receptor, making co-administration unpredictable and generally not recommended.
Actionable advice:
Avoid using together.
Target id:
/intervention/tranexamic-acid
Target name:
Tranexamic Acid
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Combining these medications significantly increases the risk of developing dangerous blood clots in veins or arteries.
Actionable advice:
Use combination with extreme caution.
Target id:
/dietary/grapefruit-pomelo
Target name:
Grapefruit, Pomelo, and Seville Oranges
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Grapefruit blocks an enzyme, increasing absorption and levels of oral estradiol, raising side effect risk.
Actionable advice:
Strictly avoid grapefruit products.
Target id:
/intervention/bile-acid-sequestrants
Target name:
Bile Acid Sequestrants
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
These cholesterol drugs can bind to estradiol in the gut, preventing its proper absorption.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/levothyroxine
Target name:
Levothyroxine
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Estradiol can reduce the amount of active thyroid hormone, making your thyroid medication less effective.
Actionable advice:
Thyroid function tests are needed.
Target id:
/intervention/progesterone
Target name:
Progesterone
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Progesterone is often required with estrogen to protect the uterine lining from overgrowth.
Actionable advice:
Take as prescribed with estrogen.
Target id:
/intervention/amiodarone
Target name:
Amiodarone
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Amiodarone can increase estradiol levels, raising the risk of side effects like nausea or breast tenderness.
Actionable advice:
Monitor for estrogen-related side effects.
Target id:
/intervention/statins
Target name:
Statins
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Estradiol and certain statins can increase each other's blood levels, raising the risk of side effects.
Actionable advice:
Monitor for muscle pain or nausea.
Target id:
/intervention/dhea
Target name:
DHEA
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
DHEA is a precursor hormone that can convert to estrogen, potentially causing excessively high levels.
Actionable advice:
Avoid co-administration without medical guidance.
Target id:
/intervention/smoking-cessation
Target name:
Smoking Cessation
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Quitting smoking can increase estradiol levels, as tobacco smoke speeds up its breakdown.
Actionable advice:
Monitor levels after quitting.
Target id:
/intervention/testosterone
Target name:
Testosterone
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Testosterone can oppose the effects of estradiol, potentially causing unwanted masculinizing side effects.
Actionable advice:
Requires careful hormone level monitoring.
Target id:
/intervention/cannabis
Target name:
Cannabis
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
CBD in cannabis can slow estradiol breakdown, potentially increasing its levels and side effects.
Actionable advice:
Use with caution; monitor effects.
Target id:
/intervention/phytoestrogens-soy-isoflavones
Target name:
Phytoestrogens: Soy Isoflavones
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
High intake of soy isoflavones can compete with estradiol, potentially weakening its intended therapeutic effects.
Actionable advice:
Moderate soy intake.
Target id:
/intervention/resveratrol
Target name:
Resveratrol
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Resveratrol may increase estradiol levels and has its own estrogen-like effects, compounding potential side effects.
Actionable advice:
Use with caution.
Target id:
/intervention/milk-thistle
Target name:
Milk Thistle (Silymarin)
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Milk thistle may slow the breakdown of estradiol, potentially increasing its levels and side effects.
Actionable advice:
Monitor for estrogen-related side effects.
Target id:
/intervention/ashwagandha
Target name:
Ashwagandha
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
Ashwagandha may slightly speed up estradiol breakdown, potentially reducing its effectiveness over time.
Actionable advice:
Monitor therapeutic effect.
Target id:
/intervention/quercetin
Target name:
Quercetin
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Quercetin may slow the breakdown of estradiol, potentially increasing its levels and side effects.
Actionable advice:
Monitor for estrogen-related side effects.
Target id:
/intervention/cruciferous-vegetables
Target name:
Cruciferous Vegetables
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
High intake of broccoli or kale can slightly increase estrogen metabolism, potentially lowering its effects.
Actionable advice:
Maintain consistent dietary habits.