Estradiol cypionate is a long-acting, bioidentical form of estrogen used in hormone replacement therapy. It works by replacing the declining levels of estrogen in menopausal women, thereby binding to estrogen receptors throughout the body to alleviate symptoms like hot flashes, night sweats, and vaginal atrophy.
Verdict
Highly effective for menopausal symptoms; requires careful medical risk assessment.
HEALTHSPAN IMPACT
Foundational
RISK LEVEL
High
EVIDENCE GRADE
A
MONTHLY COST
$20 - $60
Protocol
- Typically 1-5 mg injected intramuscularly every 3 to 4 weeks for menopausal symptoms.
Flags
- Increased risk of venous thromboembolism (VTE), stroke, and myocardial infarction.
- Unopposed estrogen increases the risk of endometrial hyperplasia and cancer in women with a uterus.
- May increase the risk of breast cancer with long-term use.
- Contraindicated in individuals with a history of certain cancers, VTE, or liver disease.
- Requires co-administration with a progestin for uterine protection in women with a uterus.