Meta Information
ID:eleuthero
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/intervention/digoxin
Target name:
Digoxin
Severity:
major
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
null
Description:
Eleuthero can interfere with laboratory tests used to measure digoxin levels, causing falsely elevated readings and potentially leading to incorrect dosing. It may also increase digoxin's effects, raising the risk of toxicity.
Actionable advice:
Avoid taking Eleuthero completely if you are prescribed digoxin.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Eleuthero may have antiplatelet properties, which could add to the effects of blood-thinning medications and increase the risk of bleeding or bruising.
Actionable advice:
Consult your doctor before using Eleuthero if you take any blood-thinning medications.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Eleuthero may lower blood sugar levels. Combining it with diabetes medications can increase the risk of hypoglycemia (dangerously low blood sugar).
Actionable advice:
Monitor blood glucose closely and consult your doctor before combining with diabetes medications.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Eleuthero may affect blood pressure, sometimes raising it, which can interfere with the effectiveness of medications intended to lower blood pressure.
Actionable advice:
Monitor blood pressure carefully if combining, and avoid Eleuthero if you have uncontrolled hypertension.
Target id:
/class/immunosuppressants
Target name:
Immunosuppressant Medications
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Eleuthero is thought to stimulate the immune system, which may counteract the effects of medications designed to suppress immune activity, such as those used after organ transplants or for autoimmune diseases.
Actionable advice:
Avoid Eleuthero if you are taking immunosuppressant medications.
Target id:
/condition/bipolar-disorder
Target name:
Bipolar Disorder
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The stimulating effects of Eleuthero could potentially trigger manic episodes in individuals with bipolar disorder.
Actionable advice:
Avoid using Eleuthero if you have bipolar disorder, especially if you are prone to mania.
Target id:
/condition/autoimmune-disease
Target name:
Autoimmune Diseases
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
By stimulating the immune system, Eleuthero could theoretically worsen symptoms of autoimmune conditions where the immune system is overactive, such as rheumatoid arthritis or lupus.
Actionable advice:
Consult your doctor before using Eleuthero if you have an autoimmune condition.
Target id:
/condition/hormone-sensitive-cancers
Target name:
Hormone-Sensitive Cancers
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is a theoretical concern that Eleuthero may have weak estrogen-like effects, which could potentially be harmful for individuals with hormone-sensitive conditions like estrogen-receptor-positive breast cancer.
Actionable advice:
Avoid Eleuthero if you have a history of a hormone-sensitive cancer.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
6
Hours after target:
0
Description:
As an adaptogen with potential stimulating properties, Eleuthero can interfere with sleep onset and quality if taken too close to bedtime.
Actionable advice:
Take your Eleuthero dose in the morning or early afternoon, at least 6 hours before you plan to sleep.
Target id:
/class/cyp2c9-substrates
Target name:
Drugs Metabolized by CYP2C9
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
In laboratory studies, Eleuthero has shown potential to inhibit the CYP2C9 enzyme, which could theoretically increase levels of medications like warfarin or phenytoin, though clinical significance is unclear.
Actionable advice:
Use with caution and consult a healthcare professional if taking medications metabolized by CYP2C9.
Target id:
/class/cyp2e1-substrates
Target name:
Drugs Metabolized by CYP2E1
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Eleuthero may inhibit the CYP2E1 enzyme in the liver, which could alter the metabolism of certain substances like acetaminophen and alcohol. The clinical relevance of this is not well established.
Actionable advice:
Exercise caution when combining with alcohol or high doses of acetaminophen.
Target id:
/intervention/caffeine
Target name:
Caffeine
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining the mild stimulating effects of Eleuthero with caffeine may lead to an additive effect, potentially causing overstimulation, jitteriness, or difficulty sleeping.
Actionable advice:
Be mindful of your total stimulant intake and consider reducing caffeine when taking Eleuthero.
Target id:
/class/stimulants
Target name:
Stimulant Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The stimulating properties of Eleuthero can be additive with prescription stimulants (e.g., for ADHD), potentially increasing the risk of side effects like increased heart rate, anxiety, and insomnia.
Actionable advice:
Avoid combining with prescription stimulants unless approved and monitored by your doctor.
Target id:
/class/cns-depressants
Target name:
Sedative-Hypnotic Drugs
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Due to its potential stimulating effects, Eleuthero might counteract the intended effects of sedatives or medications that depress the central nervous system, such as benzodiazepines or sleep aids.
Actionable advice:
Be aware that Eleuthero might reduce the effectiveness of sleep or anti-anxiety medications.
Target id:
/dietary/alcohol-acute
Target name:
Alcohol
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Eleuthero's stimulating effects may mask the sedative effects of alcohol, potentially leading to excessive consumption. It may also alter how alcohol is metabolized by the body.
Actionable advice:
Use caution when consuming alcohol while taking Eleuthero.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is insufficient reliable safety data to determine if Eleuthero is safe for use during pregnancy.
Actionable advice:
Avoid using Eleuthero completely during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is not known if the components of Eleuthero pass into breast milk or what effects they might have on a nursing infant.
Actionable advice:
Avoid using Eleuthero completely while breastfeeding.