Meta Information

ID:dronedarone

Name:Dronedarone

Schema Version:1.5

Alternate Names

• Multaq

Active Compound

dronedarone

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:rx_drug
• eu:rx_drug

Indication

Focus:

disease_treatment

Description:

To reduce the risk of hospitalization for paroxysmal or persistent atrial fibrillation (AFib) or atrial flutter.

Typical Protocol

• 400 mg taken orally twice daily with morning and evening meals.

Expected Cost Mean

Low Cost:

450

High Cost:

700

Cost Type:

monthly

Description:

Prescription drug cost, often covered by insurance for its approved indication.

Summary

Dronedarone is an antiarrhythmic drug used to treat specific types of atrial fibrillation. It works by blocking multiple ion channels in heart muscle cells to help maintain a normal heart rhythm. Its primary clinical benefit is reducing the need for hospitalization in patients with a history of paroxysmal or persistent AFib.

Purpose

Treats atrial fibrillation to reduce risk of hospitalization.

Card Summary

A prescription antiarrhythmic drug for specific types of atrial fibrillation.

Drug Class

class_iii_antiarrhythmic

Drugs In Class

Empty Array

Impact

Score:

7

Justification:

Effective at reducing hospitalization risk for specific types of atrial fibrillation.

Evidence

Grade:

A

Score:

9.5

Justification:

Supported by multiple large-scale, randomized controlled trials (RCTs) and meta-analyses.

Safety

Score:

7.8

Justification:

Black box warning for increased mortality in patients with permanent AFib or heart failure.

Flags

• Black box warning: Increased risk of death, stroke, and heart failure in patients with permanent atrial fibrillation.
• Contraindicated in patients with symptomatic heart failure with recent decompensation or NYHA Class IV heart failure.
• Risk of severe liver injury, including cases requiring liver transplantation.
• Interacts with many common drugs, including strong CYP3A4 inhibitors (e.g., ketoconazole, grapefruit juice) and inducers.
• Can cause QT interval prolongation, increasing the risk of dangerous arrhythmias (Torsades de pointes).
• Common side effects include diarrhea, nausea, abdominal pain, and bradycardia (slow heart rate).

Verdict

A specialized drug for AFib with serious risks requiring expert supervision.

Qualifier

scope: systemic, focused on disease treatment

Created

2026-05-02T02:11:50.612595Z

Ai Model

Gemini 2.5 Pro (High)

Non Healthspan

True