DHEA is a precursor hormone produced by the adrenal glands whose levels decline significantly with age. Supplementation aims to restore youthful concentrations, with the hypothesis that this may counteract some aspects of aging. Its primary mechanism is conversion into downstream sex hormones like testosterone and estrogen, making its effects highly variable and sex-dependent.
Verdict
Potentially useful for deficiency, but unproven for general healthspan extension.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Moderate
EVIDENCE GRADE
B
MONTHLY COST
$5 - $25
Protocol
- Typical doses range from 10-50 mg daily, often taken in the morning.
- Blood levels are often tested to guide dosage and avoid supraphysiological levels.
Flags
- May increase risk or progression of hormone-sensitive cancers (e.g., prostate, breast).
- Can cause androgenic side effects like acne, oily skin, and hirsutism.
- Banned by many sports organizations (WADA) as an anabolic agent.
- Use should be guided by blood tests to avoid supraphysiological hormone levels.