Meta Information

ID:dasatinib

Name:Dasatinib

Schema Version:1.5

Title

Dasatinib

Alternate Names

• Sprycel

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

300

High Cost:

800

Cost Type:

one time

Description:

Cost per intermittent dosing cycle (2-3 pills) without insurance coverage.

Summary

Dasatinib is a tyrosine kinase inhibitor, a type of chemotherapy drug, that functions as a potent senolytic. In a healthspan context, it selectively triggers apoptosis (programmed cell death) in senescent cells. These dysfunctional 'zombie' cells accumulate with age, driving chronic inflammation and tissue degradation, so their periodic removal is hypothesized to mitigate aspects of the aging process.

Purpose

A potent senolytic drug that clears aged, dysfunctional cells.

Card Summary

A potent prescription senolytic drug that selectively eliminates dysfunctional, aged (senescent) cells to reduce age-related inflammation and tissue damage.

Drug Class

tyrosine-kinase-inhibitors

Drugs In Class

Empty Array

Impact

Score:

7.2

Justification:

Potent senolytic with potential to systemically reduce age-related cellular dysfunction.

Evidence

Grade:

B

Score:

6.5

Justification:

Positive human trials show senescent cell clearance, but lacks long-term healthspan outcomes.

Safety

Score:

7.8

Justification:

Potent chemotherapy drug with significant side effects; requires strict medical supervision.

Flags

• Requires a prescription and close medical supervision.
• Significant side effect profile including fatigue, fluid retention, and myelosuppression.
• Interacts with CYP3A4 inhibitors/inducers (e.g., grapefruit juice, St. John's Wort).
• Often used with Quercetin as part of the 'D+Q' senolytic protocol.
• Long-term safety of intermittent use for longevity is not yet established.

Verdict

A powerful but high-risk senolytic for the advanced and medically supervised.

Created

2026-04-23T23:25:09.726391Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

disease_treatment

Description:

Dasatinib is a tyrosine kinase inhibitor, a type of chemotherapy drug, that functions as a potent senolytic. In a healthspan context, it selectively triggers apoptosis (programmed cell death) in senes...

Typical Protocol

• Typically used intermittently with Quercetin (e.g., 100mg Dasatinib for 2-3 days monthly/quarterly).