Meta Information
ID:d3-k2-with-calcium
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/dietary/high-fat-meal
Target name:
Meal Containing Fat
Severity:
moderate
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Vitamins D3 and K2 are fat-soluble, and their absorption from the gut is significantly enhanced when consumed with dietary fats.
Actionable advice:
Take this supplement with a meal that contains healthy fats like olive oil, avocado, or nuts.
Target id:
/intervention/warfarin
Target name:
Warfarin (Coumadin)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin K is essential for blood clotting and directly counteracts the anticoagulant effect of warfarin, potentially leading to treatment failure and dangerous blood clots.
Actionable advice:
Avoid this supplement completely if you are taking warfarin, unless specifically directed and monitored by your physician.
Target id:
/class/chelating-antibiotics
Target name:
Chelating Antibiotics (Tetracyclines, Quinolones)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
2
Description:
Calcium binds to tetracycline and quinolone antibiotics in the gut, forming an insoluble complex that prevents the antibiotic from being absorbed and working effectively.
Actionable advice:
Take this supplement at least 2 hours before or 4-6 hours after taking these types of antibiotics.
Target id:
/intervention/levothyroxine_systemic_disease
Target name:
Levothyroxine
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
4
Description:
Calcium can bind to levothyroxine in the gastrointestinal tract, significantly reducing its absorption and effectiveness.
Actionable advice:
Separate doses of this supplement and levothyroxine by at least 4 hours.
Target id:
/condition/hypercalcemia
Target name:
Hypercalcemia (High Blood Calcium)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
This supplement directly increases calcium levels and is absolutely contraindicated in individuals who already have high blood calcium.
Actionable advice:
Do not take this supplement if you have been diagnosed with hypercalcemia.
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Impaired kidneys cannot effectively clear excess calcium, and high vitamin D can worsen this, leading to dangerous mineral deposits and hypercalcemia.
Actionable advice:
Avoid this supplement if you have significant kidney disease, unless under strict medical supervision.
Target id:
/intervention/digoxin
Target name:
Digoxin
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
High blood calcium levels, a potential side effect of this supplement, can increase the risk of serious heart rhythm problems (toxicity) from digoxin.
Actionable advice:
Avoid high doses and monitor calcium levels closely if taking digoxin.
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Calcium supplements can significantly reduce the absorption of oral bisphosphonates, medications used to treat osteoporosis.
Actionable advice:
Take this supplement at least 2 hours after taking an oral bisphosphonate medication.
Target id:
/class/bile-acid-sequestrants
Target name:
Bile Acid Sequestrants & Binders
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
1
Description:
These medications can bind to fat-soluble vitamins (D and K) in the gut, preventing their absorption.
Actionable advice:
Take this supplement at least 1 hour before or 4-6 hours after taking bile acid sequestrants.
Target id:
/class/thiazide-diuretics
Target name:
Thiazide Diuretics
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Thiazide diuretics decrease the urinary excretion of calcium. Combining them with this supplement can lead to dangerously high blood calcium levels (hypercalcemia).
Actionable advice:
Use with caution and monitor serum calcium levels regularly if taking thiazide diuretics.
Target id:
/intervention/iron-bisglycinate
Target name:
Iron Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Calcium and iron compete for the same absorption pathway in the gut, and taking them together can reduce the absorption of iron.
Actionable advice:
Separate doses of this supplement and iron supplements by at least 2 hours.
Target id:
/intervention/magnesium
Target name:
Magnesium Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
High doses of calcium can compete with magnesium for absorption in the gut, potentially reducing magnesium uptake.
Actionable advice:
Separate doses of this supplement and magnesium by at least 2 hours.
Target id:
/intervention/zinc
Target name:
Zinc Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
High doses of calcium can interfere with the absorption of zinc by competing for the same intestinal transporters.
Actionable advice:
Separate doses of this supplement and zinc by at least 2 hours.
Target id:
/class/corticosteroids
Target name:
Corticosteroids
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Long-term use of corticosteroids can impair vitamin D metabolism and reduce calcium absorption, increasing the risk of osteoporosis.
Actionable advice:
If on long-term corticosteroids, consult your doctor about the need for this supplement.
Target id:
/class/anticonvulsants
Target name:
Enzyme-Inducing Anticonvulsant Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Certain anticonvulsants (e.g., phenytoin, phenobarbital) increase the liver's breakdown of vitamin D, potentially leading to deficiency.
Actionable advice:
Monitor vitamin D levels closely if taking these medications; dose adjustments may be necessary.
Target id:
/condition/history-of-kidney-stones
Target name:
History of Calcium Oxalate Kidney Stones
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Supplemental calcium, particularly without adequate fluid intake, can increase the risk of forming new calcium-based kidney stones in susceptible individuals.
Actionable advice:
Consult your doctor before using this supplement if you have a history of kidney stones.
Target id:
/biomarker/serum-calcium
Target name:
Serum Calcium
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Long-term or high-dose supplementation directly affects blood calcium levels, which should be monitored to prevent hypercalcemia.
Actionable advice:
Periodically check your serum calcium levels with your doctor while taking this supplement.
Target id:
/biomarker/vitamin-d
Target name:
25-OH Vitamin D
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
This supplement directly raises Vitamin D levels; regular testing is needed to ensure you are in the optimal range and to avoid toxicity.
Actionable advice:
Monitor your 25(OH)D levels to guide appropriate dosing and prevent excess.
Target id:
/biomarker/bone-mineral-density
Target name:
Bone Mineral Density
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin D enhances calcium absorption, while Vitamin K2 helps direct the absorbed calcium into bones, working together to support bone density.
Actionable advice:
This combination is designed to synergistically support bone health and calcium metabolism.
Target id:
/class/acid-suppressors
Target name:
Gastric Acid Suppressors
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Medications that reduce stomach acid (like PPIs) can decrease the absorption of calcium carbonate, a common form of calcium supplement.
Actionable advice:
If using acid-suppressing medication, consider a calcium citrate supplement instead, or discuss with your doctor.
Target id:
/dietary/phytate-rich-foods
Target name:
High-Oxalate/Phytate Foods (e.g., Spinach, Beans, Nuts)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Oxalates and phytates, found in many plant foods, can bind to calcium in the gut, forming insoluble complexes that prevent its absorption.
Actionable advice:
For best absorption, take at least 2 hours apart from meals very high in spinach, beans, or whole grains.
Target id:
/class/viscous-fibers
Target name:
Gel-Forming Viscous Fibers
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Large amounts of dietary fiber, especially from supplements like psyllium, can bind to minerals and slightly decrease calcium absorption.
Actionable advice:
Separate this supplement from high-dose fiber supplements by at least 2 hours.
Target id:
/class/calcium-channel-blockers
Target name:
Calcium Channel Blockers
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is a theoretical concern that high levels of supplemental calcium could counteract the therapeutic effects of calcium channel blockers, though this is rarely clinically significant.
Actionable advice:
Consult your doctor before taking high-dose calcium if you are on a calcium channel blocker.