Meta Information
ID:curcumin
Name:Curcumin
Schema Version:1.5
Alternate Names
- Turmeric
- Diferuloylmethane
- Meriva
- Longvida
- BCM-95
- Theracurmin
Active Compound
Curcumin
Intervention Type
therapeutic_agent
Delivery
Route:
oral
Scope:
- systemic
Regulatory Status
- us:dietary_supplement
- eu:food_additive_E100
Indication
Focus:
- healthspan
- symptom_management
Description:
Targets systemic inflammation and oxidative stress, and manages symptoms of inflammatory conditions like osteoarthritis.
Typical Protocol
- Take 500-1000 mg of a high-bioavailability curcumin formulation once or twice daily with food.
Expected Cost Mean
Low Cost:
15
High Cost:
40
Cost Type:
monthly
Description:
Cost for a 30-day supply of a high-bioavailability supplement; not insurance covered.
Summary
Curcumin is the primary bioactive polyphenol in turmeric, known for its potent anti-inflammatory and antioxidant properties. Its main mechanism involves inhibiting NF-κB, a key signaling pathway that controls the expression of pro-inflammatory genes. By mitigating chronic, low-grade inflammation ('inflammaging'), curcumin is thought to combat a central driver of many age-related diseases.
Purpose
A polyphenol from turmeric that targets systemic inflammation and oxidative stress.
Card Summary
A potent anti-inflammatory compound from turmeric, studied for reducing chronic inflammation and oxidative stress, key drivers of aging.
Drug Class
null
Drugs In Class
Empty Array
Impact
Score:
4.5
Justification:
Effectively targets inflammation, a key aging driver, but lacks robust longevity data.
Evidence
Grade:
A
Score:
8.5
Justification:
Extensive human RCTs and meta-analyses on inflammation and specific conditions like osteoarthritis.
Safety
Score:
3
Justification:
Generally recognized as safe (GRAS) with mild, dose-dependent gastrointestinal side effects.
Flags
- Poor bioavailability requires enhanced formulations (e.g., with piperine or lipids) for efficacy.
- May interact with anticoagulant and antiplatelet drugs, increasing bleeding risk.
- High doses can cause gastrointestinal distress, such as nausea or diarrhea.
- May interfere with iron absorption.
Verdict
A well-tolerated supplement for managing inflammation, but bioavailability is a key challenge.
Created
2026-05-05T21:59:03.415402Z
Ai Model
Gemini 2.5 Pro (High)