Meta Information
ID:creatine
Name:Creatine Monohydrate
Schema Version:1.5
Alternate Names
- Creatine
Active Compound
Creatine
Intervention Type
therapeutic_agent
Delivery
Route:
oral
Scope:
- systemic
Regulatory Status
- us:dietary_supplement
- eu:food_supplement
Indication
Focus:
healthspan
Description:
Primarily targets cellular energy metabolism, muscle mass maintenance (sarcopenia), and cognitive function, which are key pillars of healthspan.
Typical Protocol
- A daily maintenance dose of 3-5 grams is common for long-term use.
- A 'loading phase' of 20 grams per day for 5-7 days is optional and not required for long-term benefits.
Expected Cost Mean
Low Cost:
10
High Cost:
25
Cost Type:
monthly
Description:
Cost for bulk powder form; typically not covered by insurance.
Summary
Creatine is a naturally occurring compound that plays a critical role in cellular energy recycling by regenerating ATP, the primary energy currency, in muscle and brain tissue. Supplementation increases phosphocreatine stores, enhancing high-intensity performance, supporting muscle mass retention against age-related sarcopenia, and potentially improving cognitive function and mood.
Purpose
Boosts cellular energy for muscle, brain, and bone health.
Card Summary
A well-researched supplement that enhances cellular energy, supporting muscle mass, strength, and cognitive function, key components of maintaining vitality with age.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
5.8
Justification:
Strong benefits for sarcopenia prevention and cognitive support, key healthspan pillars.
Evidence
Grade:
A
Score:
9.5
Justification:
Extensive human RCTs and meta-analyses confirm efficacy for muscle and performance.
Safety
Score:
2.5
Justification:
Extremely well-studied with an excellent safety profile; GRAS status.
Flags
- May cause minor gastrointestinal distress or water retention, especially during a loading phase.
- Individuals with pre-existing kidney disease should consult a physician before use.
- Ensure adequate hydration, as creatine draws water into muscle cells.
Verdict
A safe, effective, and low-cost intervention for muscle and brain health.
Created
2026-05-05T21:58:46.912021Z
Ai Model
Gemini 2.5 Pro (High)