Meta Information
ID:cnm-au8
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety of CNM-Au8 during human pregnancy has not been established, and the potential risks to a developing fetus are unknown.
Actionable advice:
Avoid completely if you are pregnant, planning to become pregnant, or suspect you may be pregnant.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is not known whether gold nanocrystals from CNM-Au8 are excreted in human breast milk or what effects they might have on a nursing infant.
Actionable advice:
Avoid completely while breastfeeding.
Target id:
/condition/gold-allergy
Target name:
Known Gold Allergy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Individuals with a known hypersensitivity to gold, often identified through reactions to gold jewelry, are at high risk of a severe allergic reaction.
Actionable advice:
Do not take this intervention if you have a known allergy to gold.
Target id:
/class/gold-compounds
Target name:
Other Gold-Containing Therapies
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Concurrent use with other gold-containing medications (e.g., auranofin for rheumatoid arthritis) can lead to cumulative gold exposure and an increased risk of gold-related toxicity.
Actionable advice:
Avoid using with any other medications or supplements that contain gold.
Target id:
/condition/hepatic-impairment
Target name:
Severe Hepatic Impairment
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
CNM-Au8 is cleared from the body via the liver and biliary system; severe liver disease could impair its elimination, potentially leading to accumulation and adverse effects.
Actionable advice:
Use only with caution and under strict medical supervision in cases of severe liver disease.
Target id:
/class/chelating-minerals
Target name:
Strong Chelating Agents
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
4
Description:
Prescription chelating agents (e.g., EDTA, DMSA, penicillamine) are designed to bind metals and could theoretically bind to and inactivate the gold nanocrystals, reducing their efficacy.
Actionable advice:
Separate administration from prescription chelating agents by at least 4 hours.
Target id:
/biomarker/comprehensive-liver-function-panel
Target name:
Liver Function Panel (ALT, AST, Bili)
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Periodic monitoring of liver enzymes is a prudent safety measure because CNM-Au8 is cleared from the body via the hepatobiliary route.
Actionable advice:
Obtain baseline and periodic liver function tests as recommended by your healthcare provider.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
2
Description:
While no specific food interaction is known, taking CNM-Au8 on an empty stomach helps ensure more consistent absorption and gastrointestinal transit time from dose to dose.
Actionable advice:
For optimal consistency, take at least 1 hour before or 2 hours after eating.
Target id:
/class/photosensitizing-agents
Target name:
Photosensitizing Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is a theoretical risk of increased skin sensitivity to sunlight with gold compounds; this risk may be additive when taken with other photosensitizing drugs (e.g., tetracyclines, St. John's Wort).
Actionable advice:
Use extra sun protection, such as sunscreen and protective clothing, if taking alongside other photosensitizing agents.
Target id:
/intervention/sunscreen
Target name:
Broad-Spectrum Sunscreen (SPF)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Due to a theoretical, though low, risk of photosensitivity associated with gold compounds, consistent use of sunscreen is a prudent protective measure.
Actionable advice:
Apply broad-spectrum sunscreen daily to minimize any potential risk of sun sensitivity.
Target id:
/condition/renal-impairment
Target name:
Severe Renal Impairment
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Although elimination of CNM-Au8 is primarily non-renal, its effects in patients with severe kidney disease have not been formally studied, which warrants caution.
Actionable advice:
Consult your physician before use if you have severe kidney disease.