Citicoline is a naturally occurring compound that serves as a precursor to both choline and cytidine. It supports brain health by increasing the synthesis of phosphatidylcholine, a key component of neuronal cell membranes, and by boosting levels of crucial neurotransmitters like acetylcholine, potentially enhancing cognitive function and protecting against age-related neuronal damage.
Verdict
A safe, targeted supplement for supporting cognitive function during aging.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$20 - $50
Protocol
- Typical daily doses range from 250 mg to 1000 mg, often split into two administrations.
Flags
- May cause mild digestive upset or headache in sensitive individuals.
- Individuals with trimethylaminuria (TMAU) should use choline sources with caution.
- Consult a physician if taking other cholinergic drugs or have a history of depression.