Meta Information
ID:chromium-picolinate
Name:Chromium Picolinate
Schema Version:1.5
Alternate Names
- Chromium(III) picolinate
Active Compound
Chromium
Intervention Type
therapeutic_agent
Delivery
Route:
oral
Scope:
- systemic
Regulatory Status
- us:dietary_supplement
- eu:food_supplement
Indication
Focus:
healthspan
Description:
Aimed at improving insulin sensitivity and glucose metabolism to support overall metabolic health.
Typical Protocol
- Typical doses range from 200 to 1000 micrograms (mcg) per day, often taken with meals.
Expected Cost Mean
Low Cost:
5
High Cost:
20
Cost Type:
monthly
Description:
Widely available over-the-counter supplement; not covered by insurance.
Summary
Chromium picolinate is a nutritional supplement combining the essential mineral chromium with picolinic acid to enhance absorption. It is proposed to support healthspan by potentiating insulin action, thereby improving glucose disposal and metabolic function. However, its clinical efficacy in healthy, non-deficient individuals remains a subject of debate, with studies showing mixed and often modest results.
Purpose
Supports insulin function for improved glucose and metabolic health.
Card Summary
A mineral supplement intended to enhance insulin sensitivity and support blood sugar control, though evidence for significant healthspan benefit is weak.
Drug Class
chromium
Drugs In Class
Empty Array
Impact
Score:
2.5
Justification:
Minimal and inconsistent effects on glucose metabolism in most human studies.
Evidence
Grade:
B
Score:
4.5
Justification:
Numerous human trials exist, but results are conflicting and show minimal clinical significance.
Safety
Score:
3
Justification:
Generally recognized as safe at standard doses; rare adverse events at high intakes.
Flags
- May interact with diabetes medications (e.g., insulin, metformin); consult a physician.
- Rare case reports of kidney or liver damage have been associated with very high doses.
- Benefits are most often observed in individuals with pre-existing chromium deficiency or poor glycemic control.
Verdict
Likely unnecessary for healthy individuals; potential minor benefit for insulin resistance.
Created
2026-05-06T18:23:49.633667Z
Ai Model
Gemini 2.5 Pro (High)