CBD

CBD is a non-psychoactive compound from the cannabis plant that interacts with the body's endocannabinoid system (ECS), a key regulator of homeostasis. Its relevance to healthspan is primarily through its potential to modulate inflammation, reduce anxiety, and improve sleep quality, all of which are foundational pillars of healthy aging. Unlike THC, it has low affinity for CB1 and CB2 receptors but influences the ECS through various other mechanisms.

Verdict

Potentially useful for sleep and anxiety; direct healthspan evidence is limited.

Protocol

• Start with 10-25 mg daily, titrating up as needed for sleep or anxiety.
• Doses up to 300-600 mg have been used in clinical settings for specific conditions.

Flags

• Unregulated market can lead to inconsistent product quality and purity.
• Can interact with medications, particularly blood thinners like warfarin and certain antidepressants.
• High doses may cause elevated liver enzymes; monitoring is advised for long-term use.
• Ensure product is THC-free if drug testing is a concern.