Meta Information

ID:canagliflozin

Name:Canagliflozin

Schema Version:1.5

Alternate Names

• Invokana

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

50

High Cost:

600

Cost Type:

monthly

Description:

Monthly cost for prescription; may be covered by insurance for type 2 diabetes.

Summary

Canagliflozin is an SGLT2 inhibitor that lowers blood glucose by blocking its reabsorption in the kidneys, causing it to be excreted in urine. This mechanism has downstream effects on cellular energy sensing pathways like AMPK, mimicking aspects of caloric restriction. Its primary relevance to healthspan is its robust, evidence-backed ability to protect cardiovascular and renal function, two key systems that decline with age.

Purpose

SGLT2 inhibitor that lowers blood glucose and mimics caloric restriction.

Drug Class

sglt2-inhibitors

Drugs In Class

Empty Array

Impact

Score:

7.5

Justification:

Strong evidence for cardiovascular and renal protection, mimicking caloric restriction pathways.

Evidence

Grade:

A

Score:

9

Justification:

Multiple large-scale human RCTs show significant cardiovascular and renal benefits.

Safety

Score:

5.5

Justification:

Prescription drug with common side effects and rare but serious adverse risks.

Flags

• Increased risk of genital mycotic infections and urinary tract infections.
• Risk of euglycemic diabetic ketoacidosis (DKA), a serious medical emergency.
• May cause dehydration and hypotension, especially when combined with diuretics.
• Associated with an increased risk of bone fractures.
• Requires medical supervision and is a prescription-only medication.

Verdict

Potent cardio-renal protection, but requires medical supervision for significant side effects.

Created

2026-04-27T00:53:18.611439Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

disease_treatment

Description:

Canagliflozin is an SGLT2 inhibitor that lowers blood glucose by blocking its reabsorption in the kidneys, causing it to be excreted in urine. This mechanism has downstream effects on cellular energy ...

Typical Protocol

• 100mg taken once daily in the morning, often before the first meal.