Meta Information

ID:calcium-citrate

Name:Calcium Citrate

Schema Version:1.5

Alternate Names

• Calcium

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

25

Cost Type:

monthly

Description:

Widely available over-the-counter supplement with many affordable generic options.

Summary

Calcium citrate is a highly bioavailable form of calcium, a mineral essential for maintaining bone mineral density, nerve transmission, and muscle function. Its primary healthspan relevance is in the prevention of osteoporosis and associated fractures, a major cause of morbidity and loss of independence in older adults. However, the utility of high-dose supplementation is debated due to potential links with increased cardiovascular risk.

Purpose

Supports bone density to prevent age-related osteoporotic fractures.

Drug Class

calcium

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Crucial for bone health in at-risk populations, but not a systemic longevity agent.

Evidence

Grade:

A

Score:

9

Justification:

Extensive human RCTs and meta-analyses confirm its role in maintaining bone density.

Safety

Score:

3.8

Justification:

Generally safe, but high doses linked to kidney stones and potential cardiovascular risks.

Flags

• High doses may increase the risk of kidney stones.
• Supplementation is controversial due to potential links to increased cardiovascular calcification.
• Interferes with absorption of thyroid medications, tetracycline/quinolone antibiotics, and bisphosphonates.
• Should be co-supplemented with Vitamin D and K2 for optimal absorption and utilization.
• Dietary calcium from whole foods is generally considered superior and safer than supplementation.

Verdict

Consider for bone health if deficient; otherwise, prioritize dietary sources.

Created

2026-04-26T18:29:29.917539Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Calcium citrate is a highly bioavailable form of calcium, a mineral essential for maintaining bone mineral density, nerve transmission, and muscle function. Its primary healthspan relevance is in the ...

Typical Protocol

• Typically taken as 500-600 mg once or twice daily with food to enhance absorption.