Meta Information

ID:calcium-akg-liposomal

Name:Liposomal Calcium AKG

Schema Version:1.5

Alternate Names

• Liposomal Ca-AKG
• Liposomal Alpha-Ketoglutarate

Active Compound

alpha-ketoglutarate

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:dietary_supplement

Indication

Focus:

healthspan

Description:

Aims to support cellular metabolism, epigenetic maintenance, and potentially slow age-related decline.

Typical Protocol

• Take 300-500 mg of liposomal Ca-AKG once daily, typically in the morning on an empty stomach.

Expected Cost Mean

Low Cost:

60

High Cost:

120

Cost Type:

monthly

Description:

Premium-priced supplement due to liposomal formulation; not covered by insurance.

Summary

Calcium Alpha-Ketoglutarate (Ca-AKG) is a key metabolite in the Krebs cycle, crucial for cellular energy production. It is being studied for its potential to inhibit mTOR and act as a cofactor for epigenetic demethylation enzymes. The liposomal formulation encapsulates Ca-AKG in a lipid layer to protect it from stomach acid and enhance absorption, aiming for higher bioavailability and systemic effect compared to standard forms.

Purpose

Supports cellular energy and epigenetic health to promote longevity.

Card Summary

A bioavailable form of a key metabolic intermediate studied for its potential to extend healthspan by supporting cellular energy and epigenetic maintenance.

Drug Class

null

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Promising mouse data on lifespan, but human evidence is preliminary and lacks RCTs.

Evidence

Grade:

C

Score:

3.8

Justification:

Strong mouse lifespan studies exist, but human data is limited to observational studies.

Safety

Score:

3.2

Justification:

Generally recognized as safe (GRAS), but long-term human data is limited.

Flags

• Liposomal delivery significantly increases bioavailability; do not use standard Ca-AKG dosages.
• Human evidence is currently limited to a non-randomized, industry-sponsored observational study.
• Individuals with kidney issues or hypercalcemia should consult a physician due to the calcium content.
• Long-term effects of sustained supplementation in humans are not well-established.

Verdict

A promising but experimental agent based on strong mouse data.

Created

2026-06-12T17:51:05.787448Z

Ai Model

Gemini 2.5 Pro (High)