Boswellia serrata is a resin extract primarily known for its anti-inflammatory properties, mediated through the inhibition of 5-lipoxygenase (5-LO), an enzyme involved in leukotriene synthesis. Chronic low-grade inflammation is a significant contributor to aging and many age-related diseases, making boswellia a candidate for indirectly supporting healthspan by mitigating this process. Its primary established use is in managing symptoms of inflammatory conditions like osteoarthritis.
Verdict
Effective for inflammation management; promising indirect healthspan benefits.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$15 - $40
Protocol
- Commonly taken as 300-500 mg of standardized extract (e.g., 65% boswellic acids) orally, two to three times daily.
- Dosages may vary based on product formulation and specific inflammatory condition being addressed.
Flags
- May interact with blood thinners, potentially increasing bleeding risk.
- Can interact with immunosuppressant medications.
- Mild gastrointestinal upset (nausea, diarrhea, heartburn) is the most common side effect.
- Limited long-term healthspan-specific safety data.