Boswellia

Boswellia, derived from the Boswellia serrata tree, primarily functions by inhibiting the pro-inflammatory enzyme 5-lipoxygenase (5-LOX), thereby reducing the production of leukotrienes. Its relevance to healthspan lies in its ability to manage chronic, low-grade inflammation ('inflammaging'), a core driver of aging. By mitigating inflammatory pathways, it supports joint health, gut integrity, and potentially reduces systemic inflammation.

Verdict

A well-evidenced supplement for managing joint inflammation and pain.

Protocol

• Take 300-500 mg of standardized extract (30-65% boswellic acids) two to three times daily.

Flags

• May interact with antiplatelet/anticoagulant drugs (e.g., warfarin) and NSAIDs.
• Look for extracts standardized to at least 30% boswellic acids, particularly AKBA.
• Potential for mild gastrointestinal side effects like nausea or acid reflux.