Bile acid sequestrants are non-absorbable polymers that bind to bile acids in the intestine, preventing their reabsorption. This forces the liver to synthesize new bile acids from cholesterol, which lowers LDL cholesterol levels. This process also modulates key metabolic signaling pathways like FXR and TGR5, which can improve glycemic control and influence inflammation, making it relevant to metabolic healthspan.
Verdict
A targeted tool for lipid/glucose control with notable GI side effects.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Moderate
EVIDENCE GRADE
A
MONTHLY COST
$30 - $150
Protocol
- Dosing varies by specific drug, often starting low and titrating up to manage GI side effects.
Flags
- Can cause significant gastrointestinal side effects like bloating, constipation, and gas.
- Must be taken several hours apart from other medications to avoid absorption interference.
- May impair the absorption of fat-soluble vitamins (A, D, E, K).
- Powdered forms can be difficult to mix and have an unpleasant texture.