Meta Information

ID:berberine

Name:Berberine

Schema Version:1.5

Title

Berberine

Alternate Names

• Berberine HCL

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

20

High Cost:

45

Cost Type:

monthly

Description:

Cost for a typical 1000-1500mg daily dosage from reputable supplement brands.

Summary

Berberine is a bioactive compound extracted from several different plants. It primarily functions by activating AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. This activation mimics some of the metabolic effects of exercise and caloric restriction, leading to improved insulin sensitivity, lower blood glucose levels, and favorable changes in lipid profiles. Its relevance to healthspan is rooted in its potent ability to manage metabolic health, a key pillar of longevity.

Purpose

An AMPK activator that improves metabolic health and insulin sensitivity.

Card Summary

A plant-derived compound that activates AMPK, mimicking some effects of exercise to improve metabolic health.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

7.2

Justification:

Potent AMPK activator with significant, metformin-like effects on metabolic health and glucose control.

Evidence

Grade:

A

Score:

8.5

Justification:

Multiple human RCTs and meta-analyses confirm strong metabolic and lipid-lowering benefits.

Safety

Score:

4.2

Justification:

Generally safe but common GI side effects and significant drug interactions exist.

Flags

• Gastrointestinal distress (diarrhea, constipation, flatulence) is a common side effect.
• Inhibits CYP3A4 and other enzymes, creating potential interactions with many drugs (e.g., cyclosporine, statins).
• Can cause hypoglycemia when combined with other anti-diabetic medications.
• Should be avoided during pregnancy and breastfeeding.
• Standard formulations have low bioavailability; consider enhanced absorption forms.

Verdict

A powerful, evidence-backed tool for optimizing metabolic health.

Created

2026-04-23T22:55:20.217398Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Berberine is a bioactive compound extracted from several different plants. It primarily functions by activating AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. ...

Typical Protocol

• Take 500mg two to three times daily, typically 30 minutes before meals.