Meta Information
ID:bakuchiol
Name:Bakuchiol
Schema Version:1.5
Alternate Names
- Psoralea corylifolia extract
- Babchi oil
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
15
High Cost:
75
Cost Type:
monthly
Description:
Cost for a 30-60 day supply of topical serum or cream.
Summary
Bakuchiol is a plant-derived compound that functions as a functional analog to retinol, activating similar genetic pathways to stimulate collagen production and reduce signs of skin aging. While it improves skin health, a component of phenotypic age, its relevance and impact on systemic healthspan and longevity are currently unproven.
Purpose
A plant-based topical agent for skin health and anti-aging effects.
Card Summary
A plant-derived topical agent that functions similarly to retinol, improving skin health and appearance by boosting collagen production with less irritation.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
3.5
Justification:
Addresses skin aging (phenotypic age) but lacks evidence for systemic healthspan benefits.
Evidence
Grade:
B
Score:
6.5
Justification:
Human RCTs demonstrate retinol-like effects on skin aging with better tolerability.
Safety
Score:
2.5
Justification:
Generally well-tolerated topically; primary risk is mild skin irritation or allergy.
Flags
- Primarily addresses cosmetic/phenotypic aging of the skin, not systemic longevity.
- Efficacy is dependent on formulation concentration and stability.
- Considered a gentler alternative to retinoids but can still cause skin sensitivity.
Verdict
A well-tolerated topical for skin health with no proven systemic benefits.
Created
2026-04-26T18:49:48.383389Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
none
Scope:
- local
Is Skin Health
True
Indication
Focus:
healthspan
Description:
Bakuchiol is a plant-derived compound that functions as a functional analog to retinol, activating similar genetic pathways to stimulate collagen production and reduce signs of skin aging. While it im...
Typical Protocol
- Apply a 0.5% to 1.0% concentration cream or serum to the face once or twice daily.