Meta Information

ID:atorvastatin

Name:Atorvastatin

Schema Version:1.5

Title

Atorvastatin

Alternate Names

• Lipitor

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

20

Cost Type:

monthly

Description:

Widely available generic prescription medication.

Summary

Atorvastatin is a statin medication that inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol production. This action significantly lowers LDL cholesterol levels, a primary causal factor in atherosclerosis. Its healthspan relevance is derived from its profound, evidence-backed ability to reduce the risk of major adverse cardiovascular events like heart attacks and strokes, which are leading causes of age-related mortality and morbidity.

Purpose

Lowers LDL cholesterol to reduce risk of cardiovascular events.

Card Summary

A statin medication that lowers LDL cholesterol, significantly reducing the risk of atherosclerosis and cardiovascular disease.

Drug Class

statins

Drugs In Class

Empty Array

Impact

Score:

8

Justification:

Profoundly reduces risk of cardiovascular disease, a leading cause of age-related mortality.

Evidence

Grade:

A

Score:

10

Justification:

Extensive, multi-decade, large-scale human randomized controlled trials and meta-analyses.

Safety

Score:

4.5

Justification:

Well-tolerated but can cause muscle pain and has a small increased diabetes risk.

Flags

• Requires a prescription and medical supervision.
• Potential for muscle pain (myalgia) or, rarely, rhabdomyolysis.
• Associated with a small increased risk of developing type 2 diabetes.
• Interacts with grapefruit juice and drugs that inhibit the CYP3A4 enzyme.
• Regular blood tests are required to monitor lipid levels and liver function.

Verdict

A foundational tool for managing cardiovascular risk via LDL reduction.

Created

2026-04-23T22:54:54.814118Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

disease_treatment

Description:

Atorvastatin is a statin medication that inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol production. This action significantly lowers LDL cholesterol levels, a primary causal facto...

Typical Protocol

• Daily dosages of 10-20 mg are common for primary prevention of cardiovascular disease.