Ashwagandha

Ashwagandha is an adaptogenic herb primarily used to help the body manage stress. It works by modulating the hypothalamic-pituitary-adrenal (HPA) axis, which can lead to reduced levels of the stress hormone cortisol. From a healthspan perspective, mitigating chronic stress and high cortisol may reduce associated inflammation and cellular damage, which are known drivers of aging.

Verdict

A well-studied adaptogen for managing stress, a secondary aging driver.

Protocol

• Take 300-600 mg of a standardized root extract (e.g., KSM-66, Sensoril) daily, often split into two doses.

Flags

• May interact with sedatives, immunosuppressants, and thyroid medications.
• Avoid if you have an autoimmune condition, thyroid disorder, or are pregnant/breastfeeding.
• Rare reports of liver issues, potentially due to product contamination or adulteration.