Acetyl-L-Carnitine (ALCAR) is an amino acid derivative crucial for transporting fatty acids into mitochondria to be burned for energy. It also donates its acetyl group, which can support the synthesis of acetylcholine, a key neurotransmitter for memory and cognition. Due to its dual role in energy metabolism and brain function, it is investigated for mitigating age-related declines in these areas.
Verdict
A targeted supplement for mitochondrial and cognitive support with a good safety profile.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$15 - $40
Protocol
- Typical healthspan-focused doses range from 500 mg to 2,000 mg daily, often split into two doses.
Flags
- May cause nausea, vomiting, or a 'fishy' body odor at high doses.
- Use with caution in individuals with hypothyroidism as it may interfere with thyroid hormone action.
- May increase the effects of anticoagulant drugs like warfarin.
- Theoretically contributes to TMAO production, a controversial cardiovascular risk marker.