Acarbose is an alpha-glucosidase inhibitor that slows the breakdown of complex carbohydrates in the small intestine. This action blunts the post-meal spike in blood glucose and subsequent insulin release, a key mechanism implicated in several age-related diseases. By mimicking some effects of caloric restriction, it is studied for its potential to improve metabolic health and extend lifespan.
Verdict
A promising tool for managing glucose spikes, with manageable side effects.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Moderate
EVIDENCE GRADE
B
MONTHLY COST
$15 - $40
Protocol
- Typically taken as 25-100 mg at the beginning of carbohydrate-containing meals.
- Healthspan protocols often start with 25 mg and titrate up as tolerated to manage side effects.
Flags
- Frequent gastrointestinal side effects (flatulence, diarrhea) are common, especially at higher doses.
- Risk of hypoglycemia is low when used alone but increases when combined with other glucose-lowering drugs.
- Contraindicated in individuals with inflammatory bowel disease, colonic ulceration, or intestinal obstruction.
- Rare cases of elevated liver enzymes have been reported; periodic monitoring may be advised.