5-FU and Calcipotriol (Topical)

This is a combination topical therapy that acts as a potent senolytic, an agent that selectively destroys senescent (aged) cells. 5-Fluorouracil (5-FU), a chemotherapy drug, induces cell death in senescent cells, while calcipotriol, a vitamin D analog, enhances the local immune response to clear the resulting cellular debris. Its relevance to healthspan is as a targeted method to reduce the senescent cell burden in the skin, potentially mitigating local inflammation and improving tissue function.

Verdict

Promising topical senolytic for skin aging; systemic longevity benefits are unproven.

Protocol

• Apply a topical cream containing 0.005% calcipotriol and 5% 5-fluorouracil twice daily for 2-4 days.

Flags

• This is an off-label use of prescription medications requiring a compounding pharmacy.
• Causes significant skin irritation, redness, and peeling as part of its mechanism of action.
• Systemic healthspan or longevity benefits beyond skin are currently speculative and unproven.
• Should not be used by pregnant women or on open wounds.
• Requires a prescription and strict medical supervision.