Meta Information

ID:17-alpha-estradiol

Name:17-Alpha-Estradiol

Schema Version:1.5

Alternate Names

• 17α-estradiol
• alfatradiol

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

50

High Cost:

150

Cost Type:

monthly

Description:

Cost for research chemical supply; not a standard supplement or prescription.

Summary

17-alpha-estradiol is a non-feminizing stereoisomer of the primary female sex hormone, 17-beta-estradiol. It has famously extended median lifespan in male mice in the NIA's Interventions Testing Program (ITP), likely by improving glucose tolerance and reducing inflammation. Crucially, it does not bind strongly to classical estrogen receptors, avoiding the hormonal side effects associated with conventional estrogen therapy.

Purpose

A non-feminizing estrogen that may improve metabolic health and lifespan.

Card Summary

A non-feminizing stereoisomer of estradiol that extends lifespan in male mice, potentially by improving metabolic health without hormonal side effects.

Drug Class

estrogen

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Significant lifespan extension in male mice but lacks any human longevity data.

Evidence

Grade:

C

Score:

3

Justification:

Robust, replicated lifespan data in mice (NIA ITP); no human trials.

Safety

Score:

6.5

Justification:

Systemic long-term safety in humans is completely unknown; currently a research chemical.

Flags

• Virtually all positive evidence is from male mouse studies.
• Lacks human data for systemic use or longevity outcomes.
• Not available as a standard pharmaceutical or supplement for systemic use.
• Long-term effects of systemic administration in humans are unknown.

Verdict

Promising in mice, but entirely unproven for human healthspan.

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

17-alpha-estradiol is a non-feminizing stereoisomer of the primary female sex hormone, 17-beta-estradiol. It has famously extended median lifespan in male mice in the NIA's Interventions Testing Progr...

Typical Protocol

• Human longevity protocols are not established; animal studies use dietary administration.